Scientists Find Three Genetic Variations Associated with Childhood Obesity

Xinhua News, London, January 26 An international scientific team reported in the latest issue of Britain's "Nature and Genetics" magazine that they have discovered three new genetic mutations related to childhood obesity that will help medical researchers. Predict and even treat childhood obesity.

Researchers from the National Research Center of France and the Imperial College in London, United Kingdom, said that in this 10-year study, they have performed genome-wide genetics on thousands of obese children under 6 years old and some adult obese patients. In the association analysis, these adult subjects all began to have obesity symptoms during childhood or adolescence.

Researchers compared their genetic information with those of normal-weight individuals of the same age, and identified three previously undetected genetic variants, and 50% of childhood obesity patients were associated with these three genetic variants.

Of the three genetic variants, one that is most closely related to childhood obesity and adult obesity is located near the PTER gene, and researchers are not yet aware of its function. They estimated that one-third of children's obesity can be attributed to this genetic variation, and about one-fifth of adult obesity is related to it.

The second gene mutation is located in the NPC1 gene. Earlier research on rats has shown that this gene is related to appetite. Researchers estimate that one-tenth of childhood obesity is associated with this genetic variation.

The third gene variant is located near the MAF gene. This gene controls the production of insulin, glucagon, and glucagon-like peptides, which play a key role in the metabolism of glucose and carbohydrates in the human body. About 6% of childhood obesity is associated with this genetic variation.

The research team said in the report that the next step is to conduct more in-depth studies to confirm whether the three genes function independently. They said that the new findings and past research results in this area will help the medical community develop genetic tools to predict which children are "high-risk" obese children and intervene in advance to prevent children from developing obesity symptoms.

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