Proton pump inhibitors are not associated with colorectal cancer

Studies by American scholars have shown that long-term use of proton pump inhibitors (PPIs) is associated with hypergastrinemia, which leads to metabolic disorders that may be associated with the development of colorectal cancer, but long-term use of PPI does not increase the risk of colorectal cancer . (Gastroenterology 2007, 133: 748)

Yang, MD, a gastroenterologist at the University of Pennsylvania in Philadelphia, said that in the past, animal experiments have suggested that long-term use of PPI may be associated with colorectal cancer. They conducted a study to analyze the relationship between the two.

The study was based on the British Open Physiotherapeutic Research Database (1987-2002) and included 4432 patients with colorectal cancer and 44,292 matched controls. All participants were over 50 years old and had no cancer within the first 5 years of follow-up.

The results showed that in the total analysis, with PPI ≥ 5 years, the risk of colorectal cancer does not increase. However, in the PPI high-dose group, there was a tendency to increase the risk of colorectal cancer, but there was no statistical difference. Patients with pernicious anemia also have no increased risk of colorectal cancer.

Dr Yang stressed that clinicians should be clearly aware that long-term use of conventional doses of PPI is not associated with a significant increase in the risk of colorectal cancer; however, they can not completely exclude long-term high-dose PPI treatment for more than 10 years and risk of colorectal cancer Increased relevance. Therefore, physicians should always treat the patient with the least effective dose of PPI.

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