Phyllanthus chinensis

Scientific name: Phyllanthusurinaria L.

Alias: pearl grass, beads grass, night grass, yin and yang grass, oil grass

Species: For annual herbaceous plants.

Origin and distribution:

The Euphorbiaceae plant mainly grows in tropical and subtropical regions. India, Vietnam, the Americas, and China are all located south of the Yangtze River.

Ye Xiazhu main chemical composition:

Gallic acid, methoxy ellagic acid, oxalosterol, succinic acid, carotenoids, camellilin, ferulic acid, lignans, quercetin, short-leaved hematets, corilagin, flavonoids, dehydrogenation Zinc acid, tannins, alkaloids, rutoside, dipsole, short-leaved heptoxylate, short-leaved hematoxylin, geranium, short-leaved helicylate and dehydroabietate trimethyl ester Wait. Gallic acid is the main active ingredient and has antiviral effect.

Ye Xiazhu's processing method has a direct relationship with the curative effect.

Dali Bai Autonomous Prefecture Chinese Medicine Pharmaceutical Co., Ltd. produced the leaves under the use of Yunnan natural plant Phyllanthus urinaria L. as raw materials, its raw materials in strict accordance with the state of Chinese herbal medicine planting quality management practices (GAP) standards for planting. Yunnan Yexiazhu has been declared the income of Yunnan Province by the company's Chinese herbal medicine standards (the first domestic approval in 1992 to load the standard of Chinese herbal medicines).

It has been learned that the leaves of Rhizoma Zedoaria produced in Yunnan are stronger than other regions in terms of their active ingredient content and efficacy.

Ye Xiazhu tablets are made from the single plant Phyllanthus urinaria L. as raw materials and refined by modern preparation technology (fully retain its active ingredients).

The acute toxicity test failed to measure LD50, and the maximum tolerated dose was determined according to the “Guidelines for New Chinese Medicine Research”. The mice were given 3 ml (equivalent to 360 g/kg) of Yexiazhu extract (2 g/ml). After 7 days, no adverse reactions were observed in the animals, and an equivalent amount of 408 g/70 kg0 equivalent to the human body (70 kg) was deduced, and the actual clinical recommended amount was 30 g/d, which was lower than 1.3 times the maximum dose. Shows the safety of the drug.

Long-term Toxicity Tests were used to observe the micronucleus of murine bone marrow multi-disease cells, the chromosomal aberration of mouse meiotic metaphase I chromosomes, and the Ames test. As a result, Ye Xiazhu has no mutagenic effect in vivo and has good safety.

It has been proved by animal experiments that Ye Xiazhu Tablets has an inhibitory effect on Hepatitis B virus, and it has the functions of protecting hepatocytes and improving cell immunity.

Ye Xiazhu's anti-HBV effect in vitro:

In comparative screening of anti-HBV activity of different plants, Ye Xiazhu showed the best anti-HBV performance.

Ye Xiazhu in vitro anti-HBV-DNA effect:

The test confirmed that Ye Xiazhu has a significant inhibition of HBV-DNA and DNA polymerase activity and can inhibit the expression of HBSAG and HBEAG in 2.2.15 cell lines in a dose-dependent manner.

Ye Xiazhu's use of liver protection for animals:

Animal experiments were conducted to study the protective effects of Ye Xiazhu tablets on acute hepatic injury induced by D-galactosamine in mice and acute liver injury induced by carbon monoxide in mice. Results Ye Xiazhu high and low dose groups all had obvious protective effects on liver damage caused by chemical drugs.

Ye Xiazhu's role in improving immune function:

Animal experiments were conducted to study the effect of Ye Xiazhu tablets on the formation of E-flower buds and the thymus weight gain of animal immune organs. The results of the two tests showed that Ye Xiazhu had a significant enhancement of the immune function of animals. Improves the body's ability to resist viruses.

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